Protective Effects of Coadministration of the Vitamin E and Omega-3 on Doxorubicin-Induced Hepatotoxicity in Mice

Background: Doxorubicin is a favorite drug for feasting many malignancies. All organs' hepatic toxic effects are destructive and lead to use with caution. Then, it necessary increase antioxidants accompanied doxorubicin reduce its toxicity. Vitamin E an antioxidant harmful consequences. Omega-3 similarly. The healing capacity of E- was investigated together against doxorubicin. Methods: Thirty balb/c mice have divided weight 25 g into five equal groups six each. were classified as Control: normal saline; DOX: Doxorubicin; E: + DOX; Omega-3; Both DOX. histopathology set describe vacuolar degeneration, inflammation, necrosis. Immunohistochemistry performed estimate the expression tumor necrosis factor (TNFα), demonstrating inflammation. Results: DOX-induced injury increased TNF-α seen more than alone when co-administered vitamin omega-3. A significant decrease shown in ALT, AST, GGT, ALP levels compared control. Glutathione peroxidase Catalase enzyme activities higher group that received Vit or Omega-3. Conclusions: Co-administration repair controlling on Doxorubicin-induced liver